Work

Cease‐fire at the leading edge: New perspectives on actin filament branching, debranching, and cross‐linking

Year: 2011

Type: article

Abstract: Membrane protrusion at the leading edge of migrating cells is driven by the polymerization of actin. Recent studies using advanced imaging techniques raised a lively controversy about the morphology of these filaments; however, common ground between the two sides now appears to have been found. Here we discuss how the controversy has led to a deeper consideration of the architecture of actin networks underlying cell migration, and has helped define new challenges that lie ahead.

Source: Cytoskeleton

DOI: 10.1002/cm.20543

Authors: Casey A. Ydenberg, Benjamin A. Smith, Dennis Breitsprecher, Jeff Gelles, Bruce L. Goode

Institution: Brandeis University

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: American Heart Association, Deutsche Forschungsgemeinschaft, National Institutes of Health, National Institute of General Medical Sciences