Increased BLNK and Syk in B Cells From Chronic Graft-Versus-Host Disease Patients: Identification of Novel Therapeutic Targets
Year: 2013
Type: article
Abstract: In previous work, we found that CD27+ B cells from patients with chronic GVHD (cGVHD) are metabolically active and capable of constitutive IgG production via BAFF-associated pathways. As B Cell Receptor (BCR) signaling is vital for B cell survival and activation, we hypothesized that antigen engagement of BCR confers distinct signaling in potentially pathologic CD27+ B cells in human cGVHD. We first aimed to identify candidate genes using pathway-focused mRNA expression profiling of highly purified CD27+ and CD27- B cell populations from 3 patients with cGVHD and 3 healthy individuals.
Authors: Jessica L. Allen, George Fedoriw, Jenna Wooten, Matthew Fore, Philip A. Roehrs, Paul Armistead, James Coghill, Thomas C. Shea, Kristy Richards, Stephanie J. Lee, Krista Rowe, David Rizzieri, Nelson J. Chao, Jonathan S. Serody, Stefanie Sarantopoulos
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1977642957