The T3bgene promoter directs intestinal epithelial cell‐specific expression in transgenic mice
Year: 1999
Type: article
Abstract: Although a few promoters that direct intestinal epithelial cell-specific expression in transgenic animals have been reported, they are not necessarily appropriate for transgenic studies in terms of activity and tissue specificity. Here, we examined the tissue specificity of transgene expression directed by the 2.8-kb promoter region of the T3(b) gene, which encodes one of the non-classical major histocompatibility complex class I molecules. The transgene was expressed exclusively in the epithelial cells of the small and large intestines at high levels. The results indicate that the T3(b) promoter is useful for directing transgene expression specifically in intestinal epithelial cells.
Source: FEBS Letters
Authors: Hiroyuki Aihara, Nobuo Hiwatashi, Shinji Kumagai, Yuhichi Obata, Tooru Shimosegawa, Takayoshi Toyota, Jun-ichi Miyazaki
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1977785650