Work

Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein.

Year: 1993

Type: article

Abstract: FtsZ is an essential cell division protein in Escherichia coli that forms a ring structure at the division site under cell cycle control. The dynamic nature of the FtsZ ring suggests possible similarities to eukaryotic filament forming proteins such as tubulin. In this study we have determined that FtsZ is a GTP/GDP binding protein with GTPase activity. A short segment of FtsZ is homologous to a segment in tubulin believed to be involved in the interaction between tubulin and guanine nucleotides. A lethal ftsZ mutation, ftsZ3 (Rsa), that leads to an amino acid alteration in this homologous segment decreased GTP binding and hydrolysis, suggesting that interaction with GTP is essential for ftsZ function.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.90.3.1053

Authors: A Mukherjee, K Dai, J Lutkenhaus

Institution: University of Kansas Medical Center

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1977912508

FWCI: 8.919

Cites: 36

Cited by: 310

Related to: 8