Minding the Cs and Gs
Year: 2000
Type: article
Abstract: Successful gene therapy requires the introduction of foreign DNA into host cells. Until recently, most investigators working in this field did not realize that the DNA sequences themselves contained immune stimulatory sequences, called CpG motifs, that activate immune responses as an unintended consequence of gene delivery. DNA containing CpG motifs activates both the innate and the acquired arms of immune responses (Fig. 1). CpG-induced innate immunity is exemplified by the rapid activation of NK cells, macrophages, and dendritic cells, with the concomitant production of proinflammatory cytokines.
Source: Molecular Therapy
Author: Arthur M. Krieg
Institutions: University of Iowa, Iowa City VA Medical Center
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W1977990498