Work

The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression

Year: 2013

Type: review

Abstract: Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation.

Source: Transcription

DOI: 10.4161/trns.22600

Authors: Suhwan Chang, Shyam K. Sharan

Institutions: University of Ulsan, Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute