Work

Genetics of focal segmental glomerulosclerosis

Year: 2007

Type: article

Abstract: The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis (FSGS) and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are being investigated by in vitro and in vivo mechanistic studies. Those genes and proteins interactions seem to change susceptibility to kidney disease progression. Better understanding of their exact role in the development of FSGS may influence future therapies and outcomes in this complex disease.

Source: Pediatric Nephrology

DOI: 10.1007/s00467-007-0445-y

Authors: Robert P. Woroniecki, Jeffrey B. Kopp

Institutions: Albert Einstein College of Medicine, Children's Hospital at Montefiore, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,337