Work

NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN‐γ secretion

Year: 2006

Type: article

Abstract: Human secondary lymphoid tissues harbor NK cells that predominantly secrete cytokines in response to activation. Here, we demonstrate that these immunoregulatory NK cells assist in the Th1 polarization of primary immune responses, induced by dendritic cells. Tonsilar, but not peripheral blood NK cells enhanced the expansion of IFN-gamma-producing CD4+ T cells via their superior ability to produce IFN-gamma. Addition of IFN-gamma increased Th1 polarization while antibody blocking of this cytokine abolished NK cell-dependent Th1 polarization. Our data suggest that NK cells in secondary lymphoid organs assist priming of Th1 cells via cytokine secretion and this effect should be harnessed during vaccination against viruses and tumors.

Source: European Journal of Immunology

DOI: 10.1002/eji.200636290

Authors: Barbara Morandi, Gwenola Bougras, William A. Muller, Guido Ferlazzo, Christian Münz

Institutions: University of Messina, Rockefeller University, Cornell University, Weill Cornell Medicine

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze