Work

Roles of Kinins in the Nervous System

Year: 2015

Type: review

Abstract: The kallikrein-kinin system (KKS) is an endogenous pathway involved in many biological processes. Although primarily related to blood pressure control and inflammation, its activation goes beyond these effects. Neurogenesis and neuroprotection might be stimulated by bradykinin being of great interest for clinical applications following brain injury. This peptide is also an important player in spinal cord injury pathophysiology and recovery, in which bradykinin receptor blockers represent substantial therapeutic potential. Here, we highlight the participation of kinin receptors and especially bradykinin in mediating ischemia pathophysiology in the central and peripheral nervous systems. Moreover, we explore the recent advances on mechanistic and therapeutic targets for biological, pathological, and neural repair processes involving kinins.

Source: Cell Transplantation

DOI: 10.3727/096368915x687778

Authors: Priscilla D. Negraes, Cleber A. Trujillo, Micheli M. Pillat, Yang D. Teng, Henning Ulrich

Institutions: Universidade de São Paulo, University of California San Diego, Rady Children's Hospital-San Diego, Harvard University, VA Boston Healthcare System

Language: English

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico