Year: 2010
Type: article
Study design: Observational Study
Abstract: CONTEXT: Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults. OBJECTIVE: The aim of the study was to test the association between 25(OH)D, PTH, and mortality in older men. DESIGN AND SETTING: The prospective Osteoporotic Fractures in Men (MrOS) study was conducted at six U.S. clinical centers. PARTICIPANTS: We studied community-dwelling men at least 65 yr old (n = 1490). MAIN OUTCOME MEASURE: Multivariate-adjusted proportional hazards models estimated the hazard ratio (HR) for mortality; cause of death was classified as cancer, cardiovascular, and other by central review of death certificates. RESULTS: During 7.3 yr of follow-up, 330 (22.2%) participants died: 97 from cancer, 110 from cardiovascular disease, and 106 from other causes. The adjusted HR per sd decrease in 25(OH)D for all-cause mortality was 1.01 (95% CI, 0.89, 1.14); no association between 25(OH)D and cardiovascular or other-cause mortality was seen. Unexpectedly, lower 25(OH)D levels were modestly associated with a decreased risk of cancer mortality (adjusted HR per sd decrease, 0.80; 95% CI, 0.64, 0.99). Analyzing 25(OH)D as a categorical variable did not alter these results. Higher PTH levels (log-transformed) were associated with an increased risk of all-cause mortality (adjusted HR per sd increase, 1.15; 95% CI, 1.03, 1.29) and cardiovascular mortality (adjusted HR per sd increase in PTH, 1.21; 95% CI, 1.00, 1.45). CONCLUSIONS: In contrast to previous studies, lower 25(OH)D levels were not associated with an increased risk of all-cause or cause-specific mortality in older men. Higher PTH levels were associated with a modest increase in mortality risk.
DOI: 10.1210/jc.2010-0638
Institutions: California Pacific Medical Center, University of California San Diego, University of Minnesota, Minneapolis VA Health Care System, Minneapolis VA Medical Center, Stanford Medicine, Stanford University, University of Alabama at Birmingham, University of Pittsburgh, University of California Davis Medical Center, University of California, Davis, University of California, San Francisco, Oregon Health & Science University
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1068966504, G1343274610, G1613471689, Osteoporotic Fractures in Men, G2576967755, G2961663205, G3049017749, G321186775, G334011489, Osteoporotic Fractures in Men - MrOS Renewal, Osteoporotic Fractures in Men, Midcareer investigator award in patient oriented research (K24), G5246217528, G585648573, G6566566152, G659495149, G7771580635, G801436702, G8243955340, G972017601
OpenAlex ID: W1978143495