Work

Quantitative assessment of the genotoxicity of fecapentaenes

Year: 1991

Type: article

Abstract: Fecapentaenes are a group of fecal mutagens of microbial origin isolated from human stools. Fecapentaene-12 (F-12) and fecapentaene-14 (F-14), differing only in two carbon atoms in the side chain, are glyceryl ethers with a highly reactive chromophoric aliphatic side chain incorporating a conjugated pentaene moiety. Although these compounds are known for their genotoxicity, no test systems have been developed to precisely assess their relative genotoxicity. In this study F-12 and F-14 were assayed for their genotoxicity using the SOS Chromotest in which the induction of beta-galactosidase in E. coli PQ37 was used as a quantitative measure of biological activity. The activity obtained with F-12 and F-14 was compared with that of 4-nitroquinoline oxide (4-NQO) as the reference standard of a direct acting mutagen. While F-14 was almost as active as 4-NQO, F-12 was only about 25% as active as F-14, the higher analog.

Source: Mutation Research/Genetic Toxicology

DOI: 10.1016/0165-1218(91)90003-5

Authors: Padmanabhan P. Nair, Samina Shami, Eduardo Sainz, Joseph T. Judd, Philip R. Taylor, Arthur Schatzkin

Institutions: Agricultural Research Service, Johns Hopkins University, Beltsville Human Nutrition Research Center, Beltsville Agricultural Research Center, National Institutes of Health, National Cancer Institute

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W1978164952

FWCI: 0.84

Cites: 23

Cited by: 12

Related to: 10