Siloxyl Ether Functionalized Resins for Chemoselective Enrichment of Carboxylic Acids
Year: 2011
Type: article
Abstract: Although the carboxylic acid moiety is prevalent in many biologically produced molecules, including natural products and proteins, methods to chemoselectively target this functional group have remained elusive. Generally, strategies that utilize carboxylate nucleophilicity also promote reactions with other nucleophiles such as amines and hydroxyls. A reagent was sought to facilitate the selective isolation of carboxylic acid containing compounds from complex mixtures. Here, the development of siloxyl ether functionalized solid supports is described.
Source: Organic Letters
DOI: 10.1021/ol202376m
Authors: Darci J. Trader, Erin E. Carlson
Institutions: Indiana University Bloomington, Indiana University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1978171807