Work

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

Year: 1990

Type: article

Abstract: We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.87.24.9923

Authors: J C Eissenberg, T C James, D M Foster-Hartnett, T Hartnett, V Ngan, S C Elgin

Institutions: Saint Louis University, The University of Texas Southwestern Medical Center

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: FORMATION, STRUCTURE AND FUNCTION IN HETEROCHROMATIN, MOLECULAR CYTOGENETICS OF HETEROCHROMATIN, REGULATORY POTENTIAL OF CHRMOATIN DOMAINS