Work

Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue

Year: 2007

Type: article

Abstract: The understanding of drug delivery to organs, such as the brain, has been hampered by the inability to measure tissue drug concentrations in real time. We report an application of an optical spectroscopy technique that monitors in vivo the real-time drug concentrations in small volumes of brain tissue. This method will facilitate development of new protocols for delivery of drugs to treat brain cancers. The delivery of many anticancer drugs to the brain is limited by the presence of the blood-brain barrier (BBB). Mitoxantrone (MTX) is a water-soluble anticancer drug that poorly penetrates the BBB. It is preliminarily determined in an animal model that the brain tissue uptake of chemotherapy agents-in this demonstration, MTX-delivered intra-arterially is enhanced when the BBB is disrupted.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.2744025

Authors: Roberto Reif, Mei Wang, Shailendra Joshi, Ousama M. Aamar, Irving J. Bigio

Institutions: Boston University, Columbia University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Cancer Institute, National Institute of General Medical Sciences