Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.
Year: 1986
Type: article
Abstract: Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.
Institutions: The Wistar Institute, National Institutes of Health, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Cancer Institute, Instituto Nacional del Cáncer, National Institute of Allergy and Infectious Diseases, National Institute of Mental Health, University of Pennsylvania
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
Awards: G2057109075, G3471318205, G6001752693
OpenAlex ID: W1978507265