Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men

Year: 2009

Type: article

Abstract: To determine the relationship between 25(OH) vitamin D levels and non-melanoma skin cancer (NMSC), we performed a nested case-control study in ambulatory, elderly men enrolled in the Osteoporotic Fractures in Men (MrOS) Study. Health habit and medical history, including self-reported history of NMSC were recorded and 25(OH)D levels were measured on serum collected at baseline from a random sample of Caucasian MrOS subjects. Mean age (73 +/- 5), BMI, daily vitamin D and calcium intake were similar in the men with (n = 178) and without NMSC (n = 930), but higher levels of 25(OH)D were associated with a decreased risk of having a history of NMSC (P(trend) = 0.04). Men in the highest quintile of 25(OH)D (>30 ng/mL) had 47% lower odds of NMSC (95% CI: 0.30-0.93, p = 0.026) compared to those in the lowest quintile. Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.

Source: Cancer Causes & Control

DOI: 10.1007/s10552-009-9470-4

Authors: for the Osteoporotic Fractures in Men (MrOS) Study Group, Jean Y. Tang, Neeta Parimi, Angela Wu, W. John Boscardin, James M. Shikany, Mary-Margaret Chren, Steven R. Cummings, Ervin H. Epstein, Douglas C. Bauer

Institutions: Stanford Medicine, Stanford University, California Pacific Medical Center, University of California, San Francisco, University of Alabama at Birmingham

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,890

Funders: Prevent Cancer Foundation, American Skin Association, National Institutes of Health, National Institute on Aging, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Research Resources

OpenAlex ID: W1978526137