Work

Influence of the MexAB-OprM Multidrug Efflux System on Quorum Sensing in Pseudomonas aeruginosa

Year: 1998

Type: article

Abstract: Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation of lasI and the virulence genes.

Source: Journal of Bacteriology

DOI: 10.1128/jb.180.20.5443-5447.1998

Authors: Kelly Evans, Luciano Passador, Ramakrishnan Srikumar, Eric Tsang, Jonathon Nezezon, Keith Poole

Institutions: Queen's University, University of Rochester Medicine, University of Rochester

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Medical Research Council Canada, Natural Sciences and Engineering Research Council of Canada, Medical Research Council