Work

Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators

Year: 2010

Type: article

Abstract: Using suspended nanochannel resonators (SNRs), we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid today. The SNR consists of a cantilever that is 50 microm long, 10 microm wide, and 1.3 microm thick, with an embedded nanochannel that is 2 microm wide and 700 nm tall. The SNR has a resonance frequency near 630 kHz and exhibits a quality factor of approximately 8000 when dry and when filled with water. In addition, we introduce a new method that uses centrifugal force caused by vibration of the cantilever to trap particles at the free end. This approach eliminates the intrinsic position dependent error of the SNR and also improves the mass resolution by increasing the averaging time for each particle.

Source: Nano Letters

DOI: 10.1021/nl101107u

Authors: Jungchul Lee, Wenjiang Shen, Kris Payer, Thomas P. Burg, Scott R. Manalis

Institutions: Massachusetts Institute of Technology, Innovative Micro Technology (United States), Max Planck Society, Max Planck Institute for Biophysical Chemistry

Language: English

Topic: Acoustic Wave Resonator Technologies

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: Consortia for Improving Medicine with Innovation and Technology, Deutscher Akademischer Austauschdienst, Max-Planck-Gesellschaft, Army Research Office, Institute for Collaborative Biotechnologies

OpenAlex ID: W1978597639

FWCI: 10.49

Cites: 19

Cited by: 188

Related to: 8