Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: Results from the look AHEAD randomized trial
Year: 2011
Type: article
Abstract: Intentional weight loss is an important component of treatment for overweight patients with type 2 diabetes, but the effects on bone density are not known. We used data from the Look AHEAD trial to determine the impact of an intensive lifestyle weight loss intervention (ILI) compared with diabetes support and education (DSE) on changes in bone mineral density (BMD) over 12 months. Overweight and obese adults with type 2 diabetes were randomly assigned to ILI or DSE. In a substudy of BMD conducted at 5 of 16 clinical centers, hip, spine, and whole body dual X-ray absorptiometry scans were obtained at baseline and 1-year later on 642 of 739 ILI and 632 of 740 DSE participants. At baseline, mean age was 58.4 years, and average body mass index was 35.2 kg/m(2). Total hip BMD T-score was <-2.5 in 1% and <-1.0 in 8%. At 1 year, weight loss was greater in ILI than DSE (-8.6% versus -0.7%), and glycemic control and fitness were also improved. Bone loss over 1 year was greater in ILI at the total hip (-1.4% versus -0.4%; p < 0.001) and femoral neck (-1.5% versus -0.8%; p = 0.009), but change in BMD for the lumbar spine and whole body did not differ between groups. In ILI, bone loss at the total hip was independently associated with weight loss in men and women and with poorer glycemic control in men, but was not associated with changes in fitness. One year of an intensive lifestyle intervention in adults with type 2 diabetes, resulting in weight loss, was associated with a modest increase in hip bone loss despite improved fitness and glycemic control.
DOI: 10.1002/jbmr.1483
Institutions: University of California, San Francisco, University of Tennessee Health Science Center, University of Washington, VA Puget Sound Health Care System, University of Southern California, Wake Forest University Health Sciences, Wake Forest University, Pennington Biomedical Research Center, Louisiana State University
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Health and Human Services, U.S. Department of Veterans Affairs, LifeScan, Massachusetts General Hospital, University of Washington, Johns Hopkins University, University of Pittsburgh, National Institutes of Health, Centers for Disease Control and Prevention, National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Center on Minority Health and Health Disparities, National Center for Research Resources, Office of Research on Women's Health, National Institute on Minority Health and Health Disparities
Awards: G1017836356, G1069896169, G1086024956, G1135201380, G1149464818, G1153163889, G1187123934, G1203962249, G1231470764, G1235635717, G1315288277, G1410225327, G1428306231, G1457443466, G154671801, G1559150778, G1561916549, G1600615547, G1625418467, G1657039673, G1681235271, G1697512176, G1789861183, G1808778573, G1825392443, G1840982552, G1856819184, G1895210975, G1902398179, G1950426917, G1967037622, G2037811546, G2059390010, G2115812462, G2116049842, G2141129906, G2170701390, G2191010568, G220748524, G2247787434, G2259681657, G2279102038, G2288065837, G2310294257, G2340596590, G2379922715, G2418271037, G241913450, G2430377532, G2439251763, G2456504948, G2469879864, G2519210884, G2527449299, G2550287350, G2552013629, G2596108490, G2611529574, G2622354101, G2647539983, G2657407243, G2689375212, G2700091228, G273771255, G2740538849, G2753490813, G2780371328, G286992177, G2875079641, G3005483435, G3014266866, G3023558333, G3033840998, G3041424743, G3060641347, G307984963, G3085877500, G3090877473, G3105508146, 05/16 Action for Health in Diabetes Extension Study - Research Project, G3135437339, G316640966, G3171598973, G3192100241, G3237517486, G3314471156, G3317573464, G3353711240, G3363638228, G3363681198, G33699332, G3422150604, G3461265983, G3466474382, G346895651, G3480908756, General Clinical Research Center, G3528332946, G3529252663, G3533025948, G356129122, G357792199, G3578825160, G3667465877, G3721678628, G3728863030, G3760232349, G376410420, G380811259, G384675585, G3853493639, G386878553, G3886449313, G3915506152, G3917439771, G3953056078, G399994722, G4140582021, G4166935871, G4186509959, G420249297, G4346870246, G4451789618, G461622114, G4623107666, G4632629974, G464814791, G4691857098, G474757791, G4769937872, G4818134524, G4837651308, G489457639, G4929737355, G4936150098, G5025251112, G5032750422, G5064254831, G5085995034, G5135479248, G5171269508, G5238141603, G5244746913, G5265194600, 09/16 Action for Health in Diabetes Extension Study Research Project, G5371909057, G538488588, G5524552551, G5554796922, G5559485639, G5575737915, 08/16 Action for Health in Diabetes Extension Study Research Project, G5762116573, G5764153437, G5800301348, G5867119639, G5894676382, G5923072222, G5939482190, G595004201, G6042631268, G6046566817, G6049454397, G6070369395, G6092316905, G6095923914, G6118008579, G618628323, G620556806, G6318709474, G6463443458, G6474875500, G6478205353, G6557542294, G6652447569, G6653034873, G6672857982, G6692712374, G66933475, G6756527295, G676721179, G677419319, G6814108493, G6826129284, G6838893258, G6873664978, G6961739586, G6965014325, G6980734000, G7070944836, G7073284033, G7244940528, G7263721568, G730008748, G7348448973, G7369679316, G7370045261, G7376939847, G7377779347, G7423298715, G7479900841, G752626727, G7545046265, G7608888979, G7620569218, G7632577458, G7635948963, G7689898056, G7713411732, G77314734, G783197237, G7881544786, G799249705, G800164042, G8029094511, G803155717, G8053368382, G8057008535, G8067702301, G8101982316, G8234376591, G8315761971, G8331318852, G8334132963, G8338615354, 12/16 Action for Health in Diabetes Extension Study Research Project, G8354416363, G8365010721, G8382874639, G8389659858, G8451158733, G8479431427, G8552485703, G8568271438, G8601563202, G860858521, G8650192406, G8672970883, G8735781741, G873892145, G8783444069, G881343144, G8856669533, G8862138858, G8921639506, G89527572, G8974838662, G9000013878, G9000030515, G9000041399, G9000043935, G9000056400, G9000085504, G9000087769, G9000111718, G9000113229, G9000115744, G9000117665, G9000119805, G9000127204, G9000141685, G9000149772, G9000154395, G9000160430, G9000179820, G9000194531, G9000203865, G9000221354, G9000232522, G9000245686, G9000246354, G9000285666, Diabetes Research Center, G900410922, G91250943, G94176081, G955307958, G980169708
OpenAlex ID: W1978600482