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Subcortical brain atrophy persists even in HAART-regulated HIV disease

Year: 2011
Type: article
Study design: Observational Study
Abstract: The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy.
DOI: 10.1007/s11682-011-9113-8
Authors: James T. Becker, Joanne Sanders, Sarah K. Madsen, Ann Ragin, Lawrence Kingsley, Victoria Maruca, Bruce Cohen, Karl Goodkin, Eileen Martin, Eric N. Miller, Ned Sacktor, Jeffery R. Alger, Peter B. Barker, Priyanka Saharan, Owen T. Carmichael, Paul M. Thompson
Institutions: University of Pittsburgh, University of California, Los Angeles, Northwestern University, Allegheny College, University of Illinois Chicago, Johns Hopkins University, University of California, Davis
Language: English
Subfield: Virology
Open Access status: hybrid
Estimated APC paid: $3,790
Funders: Deutsches Krebsforschungszentrum, National Institute on Aging, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: G1648982045, G1976938093, G2017072594, G2088232294, A Multiparametric MR Study of Early and Late Stage HIV Infection, Cardiovascular and HIV/AIDS Effects on Brain Structure/Function and Cognition, G344188330, G359857122, General Clinical Research Center, Natural History of AIDS in Homosexual Men, MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH, G51363488, A Multidimensional Alzheimer's Disease Brain Atlas, Center/Coordination, Analysis and Management/MACS, Computational Modeling of High-Field MR Images, G561273952, G6120741853, MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH LABS, G690007806, Multicenter AIDS Cohort Study, G714446084, Multicenter AIDS Cohort Study - Part B (Baltimore Center)
OpenAlex ID: W1978613454
FWCI: 4.146
Cites: 37
Cited by: 167
Related to: 10