CD8+T Cell Escape Mutations in Simian Immunodeficiency Virus SIVmac239 Cause Fitness DefectsIn Vivo, and Many Revert after Transmission
Year: 2011
Type: article
Abstract: Virus-specific CD8(+) T lymphocytes select for escape mutations in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). To assess the effects of these mutations on viral fitness, we introduced escape mutations into 30 epitopes (bound by five major histocompatibility complex class I [MHC-I] molecules) in three different viruses. Two of these MHC-I alleles are associated with elite control. Two of the three viruses demonstrated reduced fitness in vivo, and 27% of the introduced mutations reverted. These findings suggest that T cell epitope diversity may not be such a daunting problem for the development of an HIV vaccine.
Source: Journal of Virology
DOI: 10.1128/jvi.05841-11
Institution: University of Wisconsin–Madison
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1226645368, G2416414340, A Novel, Logical Approach to HIV Vaccine Development, MHC Typing of Macaques Used in AIDS Research, G3934557094, G422425422, G4495922382, G4688819643, MHC-bound, SIV-derived, CTL and HTL Epitopes, G6670064158, Virology Training Grant, G8392172676, Wisconsin National Primate Research Center Support
OpenAlex ID: W1978622866