Year: 2008
Type: editorial
Abstract: Significance The authors describe the preparation for trisubstituted enol derivatives via tandem carbometalation-oxygenation of terminal alkynes. The enol derivatives were isolated as a single regioisomer with a high E -selectivity ( E / Z > 20:1). Stereodefined enol ethers can undergo asymmetric dihydroxylation to yield optically active α-hydroxy aldehydes. Finally, α-hydroxy aldehydes were shown to undergo homologation to a terminal alkyne, reductive amination, oxidation and olefination.
Source: Synfacts
Authors: J. R. DeBergh, K. M. Spivey, J. M. Ready
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W1978628751