Work

Principles of planar polarity in animal development

Year: 2011

Type: review

Abstract: Planar polarity describes the coordinated polarisation of cells or structures in the plane of a tissue. The patterning mechanisms that underlie planar polarity are well characterised in Drosophila, where many events are regulated by two pathways: the 'core' planar polarity complex and the Fat/Dachsous system. Components of both pathways also function in vertebrates and are implicated in diverse morphogenetic processes, some of which self-evidently involve planar polarisation and some of which do not. Here, we review the molecular mechanisms and cellular consequences of planar polarisation in diverse contexts, seeking to identify the common principles across the animal kingdom.

Source: Development

DOI: 10.1242/dev.054080

Authors: Lisa V. Goodrich, David Strutt

Institutions: Harvard University, University of Sheffield

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Wellcome Trust, National Institutes of Health

Awards: Dissection of Frizzled function in cell polarity establishment in Drosophila., Fat and Dachsous and the hierarchy of planar polarity gene function in Drosophila.