Year: 2012
Type: article
Abstract: Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the "brain-type diabetes." In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human "healthy" longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach.
Source: Journal of Aging Research
DOI: 10.1155/2012/384017
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,000
Awards: G2596705899, Impacto da terapia com exendina-4 nos mecanismos moleculares subjacentes à disfunção cerebral associada à diabetes tipo 2 a longo prazo, NEUROPROTECTIVE ROLE OF INSULIN AND IGF-1 AGAINST HUNTINGTON’S DISEASE-ASSOCIATED DIABETES IN VITRO AND IN VIVO, G5245282893, G5763238563, G5870962330
OpenAlex ID: W1978808714