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Serum Vitamin D Level and Prehypertension among Subjects Free of Hypertension

Year: 2011

Type: article

Abstract: BACKGROUND: Low serum vitamin D levels are associated with high blood pressure (BP). Prehypertension is a preclinical stage where primary prevention efforts have been recommended for delaying or preventing the onset of hypertension. However, the majority of studies examining the association between vitamin D and BP have not accounted for kidney function or systemic inflammation. METHODS: Participants of the 3rd National Health and Nutrition Examination Survey > 20 years of age and free of hypertension (n = 9,215, 53.5% women) and clinical cardiovascular disease were examined. Serum vitamin D levels were analyzed as quartiles. Prehypertension (n = 3,712) was defined as systolic BP 120-139 mm Hg or diastolic BP 80-89 mm Hg. RESULTS: Lower serum vitamin D levels were found to be associated with prehypertension independent of potential confounders including body mass index (BMI), serum cholesterol, C-reactive protein and estimated glomerular filtration rate. Compared to the highest quartile of serum vitamin D (referent), the odds ratio (95% confidence interval) of prehypertension associated with the lowest quartile was 1.48 (1.16-1.90; p trend < 0.0001). This association persisted in subgroup analyses by gender, race-ethnicity and BMI. CONCLUSION: Lower serum vitamin D levels are associated with prehypertension in a representative sample of US adults.

Source: Kidney & Blood Pressure Research

DOI: 10.1159/000330716

Authors: Charumathi Sabanayagam, Anoop Shankar, Shanmugasundaram Somasundaram

Institution: West Virginia University

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institute of Environmental Health Sciences