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Blocking local glucocorticoid activation improves skin thinning and impaired healing in Cushingoid mice

Year: 2014

Type: conference-abstract

Abstract: β-ACT Cushing's disease presents with multiple symptoms of systemic glucocorticoid (GC) excess including increased skin thinning and poor wound healing (WH).Local GC concentrations are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which activates cortisol or corticosterone from cortisone or 11dehydrocorticosterone in human or mouse tissues respectively, including skin (Fig. 1).We recently demonstrated elevated 11β-HSD1 activity during early WH (Tiganescu et al. 2014).Here, we hypothesize that local 11β-HSD1 blockade improves the WH delay caused by systemic GC excess. Blocking local glucocorticoid activation improves skin thinning and impaired wound healing in Cushingoid miceMethods

Source: Endocrine Abstracts

DOI: 10.1530/endoabs.34.p376

Authors: Ana Tiganescu, Yoshikazu Uchida, Peter Elias, Walter Holleran

Language: English

Topic: Adrenal Hormones and Disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1978981982

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