Work

Potential curability of newly diagnosed acute promyelocytic leukemia without use of chemotherapy: the example of liposomal all-trans retinoic acid

Year: 2005

Type: article

Abstract: interact with the N-or C-terminal region of SCL, and thus, it is speculated that ⌬bHLH SCL functions against WT SCL through the competition for binding to these proteins.To further explore the underlying biochemical mechanisms, we have sequenced some of these coprecipitated proteins, which we hope will be reported in the near future.We disagree with the comment by the questioners that we should be able to show the rescue of the effect of ⌬bHLH SCL with WT SCL.This is not an appropriate experiment to show the dominant-negative effect of ⌬bHLH SCL.Although the biochemical mechanisms need to be further disclosed, clear are our findings on the distinct biologic functions of WT SCL and ⌬bHLH SCL on the commitment fate determination of hematopoietic stem cells.We hope that our ongoing study will give a clear answer to the mechanisms for how ⌬bHLH SCL functions in a dominant-negative fashion against WT SCL.

Source: Blood

DOI: 10.1182/blood-2004-09-3437