Work

Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only of Nucleobase, Amino Acid, and Glycoside

Year: 2011

Type: article

Abstract: The integration of nucleobase, amino acid, and glycoside into a single molecule results in a novel class of supramolecular hydrogelators, which not only exhibit biocompatibility and biostability but also facilitate the entry of nucleic acids into cytosol and nuclei of cells. This work illustrates a simple way to generate an unprecedented molecular architecture from the basic biological building blocks for the development of sophisticated soft nanomaterials, including supramolecular hydrogels.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja208456k

Authors: Xinming Li, Kuang Yi, Junfeng Shi, Yuan Gao, Hsin-Chieh Lin, Bing Xu

Institution: Brandeis University

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Award: Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines