Work

Extracellular matrix and integrin-signaling in the regulation of cell growth

Year: 1999

Type: article

Abstract: The extracellular matrix (ECM) and mitogenic growth factors are jointly required for cell cycle progression through G1 phase, and this combined requirement is manifest in the regulation of the G1-phase cyclins and cyclin dependent kinase (CDK) inhibitors. One of the G1-phase cell cycle events regulated by cell adhesion is the expression of the CDK inhibitor p21. p21 is induced in early G1 phase, and this induction may play a role in assembling cyclin-CDK complexes. Down-regulation of p21 then occurs in mid-late G1, coincident with the activation of G1-phase cyclin-CDKs.

Source: Kidney International

DOI: 10.1046/j.1523-1755.1999.0560041188.x

Author: Richard K. Assoian

Institution: University of Pennsylvania

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,500