Work

T Lymphocytes Are Not Immune

Year: 2013

Type: article

Abstract: Administration of genetically modified T lymphocytes to cancer patients has increased exponentially over the past 15 years, and these cells have been given to many hundreds of patients. These studies have often used retroviral vectors, and, in sharp contrast to clinical trials using hematopoietic stem cells as targets, gene-modified T cells have not subsequently undergone malignant transformation. This has led to the impression that the more differentiated state of T lymphocytes may offer protection from retroviral mutagenesis.

Source: Molecular Therapy

DOI: 10.1038/mt.2013.102

Author: Gianpietro Dotti

Institutions: Houston Methodist, Baylor College of Medicine, Texas Children's Hospital

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500