Associations Between Hippocampal Volume and Cognitive Function in Children with Chromosome 22q11.2 Deletion Syndrome
Year: 2007
Type: other
Abstract: Chromosome 22q11.2deletion syndrome (DS22q11.2) occurs in 1-2:4000 live births as the result of a a 1.5 -3Mb deletion on chromosome 22 (Murphy & Scambler, 2005).• Syndrome is characterized by:-Intelligence scores in "borderline" range (typically PIQ > VIQ)• Impaired spatial memory, visuospatial attention, numerical and temporal cognition -Increased risk for developmental psychopathology (e.g., ADHD, OCD, Schiz)• Reduced gray and white matter in parietal regions & medial cerebellum consistently reported (e.g., Eliez et al., 2000; Simon et al., 2005) • Goal of the present investigation was to assess abnormalities of the amygdala and hippocampus in 7-to 14-year-old children with DS22q11.2 and explore associations with cognitive phenotype.• Data were acquired at 3 scanner sites using a 1.5T Siemens Vision and 2 3T Siemens Trios -For each subject, a three-dimensional high-resolution (1mm isotropic) structural MRI was acquired using a T1-weighted MP-RAGE sequence.-Although data collection site was not correlated with any of the volumetric measurements it was entered as a covariate in all analyses.• Total brain volume (gray/white matter and CSF) was calculated using SPM2.• Neuroanatomical guidelines were used to define borders of the amygdala and hippocampus bilaterally and volumes were calculated based on manual tracings of the regions (see Schumann et al., 2004 for details of procedure).
Authors: T. DeBoer, Zhilin Wu, Yukari Takarae, Vy H. Nguyen, Laura B. Gabriel, T.J. Simon
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funder: National Institutes of Health
OpenAlex ID: W198034894