Work

Abnormal Cell Responses and Role of TNF- α in Impaired Diabetic Wound Healing

Year: 2013

Type: review

Abstract: Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF- α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF- α .

Source: BioMed Research International

DOI: 10.1155/2013/754802

Authors: Fanxing Xu, Chenying Zhang, Dana T. Graves

Institutions: Dalian University of Technology, University of Pennsylvania, Peking University, Peking University School and Hospital of Stomatology

Language: English

Topic: Wound Healing and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680