Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology
Year: 2010
Type: article
Study design: Observational Study
Abstract: Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.
Source: Blood
Institutions: City Of Hope National Medical Center, City of Hope, National Cancer Institute, Science Applications International Corporation (United States), National Institutes of Health, Division of Cancer Epidemiology and Genetics, Mayo Clinic, University of Southern California, USC Norris Comprehensive Cancer Center, University of Washington, Fred Hutch Cancer Center, Wayne State University, The Barbara Ann Karmanos Cancer Institute, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Massachusetts Institute of Technology
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1041864957, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1788914148, SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS--SEER, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G386607036, G4836174358, G5185757912, G5372537626, G5888954722, G835684289
OpenAlex ID: W1980429964