Work

The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload Disorders

Year: 2011

Type: review

Abstract: The review summarizes the current understanding of the role of hepcidin and ferroportin in normal iron homeostasis and its disorders. The various approaches to therapeutic targeting of hepcidin and ferroportin in iron-overload disorders (mainly hereditary hemochromatosis and β-thalassemia) and iron-restrictive anemias (anemias associated with infections, inflammatory disorders, and certain malignancies, anemia of chronic kidney diseases, and iron-refractory iron-deficiency anemia) are also discussed.

Source: Hematology

DOI: 10.1182/asheducation-2011.1.538

Authors: Tomas Ganz, Elizabeta Nemeth

Institution: University of California, Los Angeles

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Diabetes and Digestive and Kidney Diseases