Year: 2007
Type: editorial
Abstract: Significance Cycloadditions are among the best ways to rapidly create complexity in heterocycle synthesis. Readily available diazoesters 2 can now be used in enantioselective dipolar cycloadditions with activated alkenes 1 . Previous methods were limited either to diazomethane derivatives, or did not tolerate β-substitution on the alkene (R 2 in 1 ). The method was applied to a rapid total synthesis of (-)-manzacidin A ( 6 ), where the stereochemistry of the quaternary tert -alkyl amino stereocenter was fully controlled in the key step.
Source: Synfacts
Authors: M. P. Sibi, L. M. Stanley, T. Soeta
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W1980561277