Work

Selective Reprogramming of Cd19-Specific T Cells With IL-21 and CD28 Signaling for Adoptive Immunotherapy of Acute Lymphoblastic Leukemia

Year: 2009

Type: article

Abstract: Adoptive transfer of T cells has been used to treat and prevent malignancies and opportunistic infections. To improve therapuetic efficacy, investigators initially redirected specificity through the introduction of immunoreceptors. Early-phase trials are now underway to demonstrate the safety and feasibility of CD19-specific chimeric antigen receptors (CARs) which recognize antigen independent of MHC. However, it is recognized that improving in vivo persistence will be needed to enhance therapeutic potential of CAR+ T cells.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2008.12.191