Work

The complete genomic sequence of Nocardia farcinica IFM 10152

Year: 2004

Type: article

Abstract: We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0406410101

Authors: Jun Ishikawa, Atsushi Yamashita, Yuzuru Mikami, Yasutaka Hoshino, Haruyo Kurita, Kunimoto Hotta, Tadayoshi Shiba, Masahira Hattori

Institutions: Chiba University, National Institute of Infectious Diseases, Kitasato University

Language: English

Topic: Actinomycetales infections and treatment

Subfield: Microbiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1980789643

FWCI: 29.41

Cites: 32

Cited by: 294

Related to: 10