Computational Investigation of Dynamic Properties of Actin Networks With Crosslinking Proteins
Year: 2010
Type: conference-paper
Abstract: Due to the increasing recognition of the role that force plays in biological processes, a new field, mechanobiology, has recently emerged. One aspect of this is the need to gain a physical understanding of the viscoelastic properties of the cytoskeleton. Numerous studies, both in living cells and in reconstituted actin gels, have been conducted, but important questions still remain. Of these an important issue revolves around the role played by actin crosslinking proteins (ACPs), and whether they undergo unfolding or unbinding under stress. This issue is complicated by the fact that single molecule studies show that both events occur within a similar range of forces, on the order of 20–100 pN.
Authors: Taeyoon Kim, Wonmuk Hwang, Roger D. Kamm
Institutions: Massachusetts Institute of Technology, Texas A&M University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1980829964