Work

The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

Year: 2010

Type: article

Abstract: There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.

Source: Microbes and Infection

DOI: 10.1016/j.micinf.2010.10.013

Authors: Mohlopheni J. Marakalala, Reto Guler, Lungile Matika, Graeme Murray, Muazzam Jacobs, Frank Brombacher, Antonio Gigliotti Rothfuchs, Alan Sher, Gordon D. Brown

Institutions: University of Cape Town, Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology, University of Aberdeen, Karolinska Institutet, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,510

Funders: Wellcome Trust, National Research Foundation, South African Medical Research Council, Claude Leon Foundation, University of Cape Town, Medical Research Council

Awards: The role and modulation of Dectin-1 function in innate and adaptive immunity., Dectin-1 and its role in the innate recognition of Beta-glucans and fungal pathogens.

OpenAlex ID: W1980930889

FWCI: 2.875

Cites: 17

Cited by: 56

Related to: 10