Differential Effects of ApoE Isoforms on Dendritic SpinesIn Vivo: Linking an Alzheimer's Disease Risk Factor with Synaptic Alterations
Year: 2010
Type: article
Abstract: The ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor for the development of Alzheimer's disease (AD). Accumulation of amyloid-β (Aβ) is hypothesized to initiate synaptic and neuronal dysfunction that ultimately lead to neuronal cell death in AD, and several lines of
Source: Journal of Neuroscience
Authors: Jacob M. Basak, Jungsu Kim
Institution: Washington University in St. Louis
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W1980991647