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Desacetyl vinblastine amide sulfate induced ineffective erythropoiesis

Year: 1979

Type: article

Abstract: Ineffective erythropoiesis occurred during desacetyl vinblastine amide sulfate (VDS) therapy of a patient with metastatic Ewing's sarcoma. The peripheral blood was characterized by anisocytosis, poikilocytosis and reticulocytopenia. Bone marrow showed megaloblastic red cell hyperplasia with nuclear fragmentation, binuclearity and abnormal metaphases. Radioiron incorporation into red cells was markedly decreased. Electron microscopy showed red cell surface changes previously called ropalocytosis. Normal erythropoiesis promptly resumed when VDS treatment was withheld. Although less common than leukopenia, red cell abnormalities are part of the spectrum of vinca alkaloid toxicity.

Source: Cancer

DOI: 10.1002/1097-0142(197907)44:1<64::aid-cncr2820440112>3.0.co;2-5

Authors: Hani G. Jumean, Bruce Camitta, John Holcenberg, Albertina Hodach

Institutions: Children's Hospital of Wisconsin, United States Department of Veterans Affairs, Medical College of Wisconsin

Language: English

Topic: Cancer Treatment and Pharmacology

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute