Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis
Year: 2014
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews. METHODS: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls. RESULTS: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity. CONCLUSIONS: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.
Source: PLoS ONE
Authors: Pei-Hsuan Weng, Yi-Ling Huang, John H. Page, Jen-Hau Chen, Jianfeng Xu, Stella Koutros, Sonja Berndt, Stephen Chanock, Meredith Yeager, John S. Witte, Rosalind A. Eeles, Douglas F. Easton, David E. Neal, Jenny Donovan, Freddie C. Hamdy, Kenneth R. Muir, Graham Giles, Gianluca Severi, Jeffrey R. Smith, Carmela R. Balistreri, Irene M. Shui, Yen-Ching Chen
Institutions: National Taiwan University, Taiwan Adventist Hospital, Tufts University, Jean Mayer Human Nutrition Research Center on Aging, Brigham and Women's Hospital, National Taiwan University Hospital, Wake Forest University Health Sciences, Wake Forest University, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, United States Department of Health and Human Services, Science Applications International Corporation (United States), University of California, San Francisco, Institute of Cancer Research, University of Cambridge, Addenbrooke's Hospital, University of Bristol, University of Sheffield, University of Nottingham, Queen's Medical Centre, Cancer Council Victoria, Vanderbilt University, University of Palermo, Harvard University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
OpenAlex ID: W1981266379