Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability
Year: 2010
Type: article
Study design: Observational Study
Abstract: When given challenging episodic memory tasks, young adults demonstrate notable individual differences in performance. Recent evidence suggests that individual differences in human behavior may be related to the strength of functional connectivity of large-scale functional networks as measured by spontaneous fluctuations in regional brain activity during quiet wakefulness (the "resting state"), in the absence of task performance. In this study, we sought to determine whether individual differences in memory performance could be predicted by the interhemispheric functional connectivity of the two hippocampi, hypothesized to reflect the intrinsic connectivity within the large-scale medial temporal lobe memory system. Results demonstrated that interhemispheric hippocampal functional connectivity during quiet wakefulness was predictive of the capacity to freely recall recently learned information (r = 0.47, P < 0.05). In contrast, functional connectivity of bilateral motor cortices had no relationship to free recall, supporting the specificity of the hippocampal data. Thus, individual differences in the capacity to perform episodic memory tasks, which may be persistent behavioral traits or transient states, may be at least partly subserved by individual differences in the functional connectivity of large-scale functional-anatomic memory networks.
Source: Hippocampus
DOI: 10.1002/hipo.20771
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Prospective Neuroimaging in Huntington's Disease, Morphometry Biomedical Informatics Research Network, Ultrahigh-resolution in vivo and ex vivo MRI of human medial temporal lobe, Center for Functional Imaging Technologies, Massachusetts Alzheimer's Disease Research Center, Medial temporal lobe subregions in aging, MCI and AD:Structural and functional M
OpenAlex ID: W1981458943