Year: 2010
Type: review
Abstract: The autism spectrum disorders (ASDs) are a complex group of neuropsychiatric conditions involving language, social communication, and mental flexibility. Here, we attempt to place recent genetic advances within a developmental and anatomical context. Recent progress in identifying ASD candidate genes supports involvement of multiple brain regions, including the frontal lobes, anterior temporal lobes, caudate, and cerebellum. Understanding genetic data within an anatomical context will be critical to explain how individual risk factors operate to shape phenotypic presentation in patients.
Source: Archives of Neurology
Authors: Brett S. Abrahams, Daniel H. Geschwind
Institution: University of California, Los Angeles
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Awards: G1156944221, G2499467651, G4564237680, Heterogeneity in Autism Spectrum Disorders: Biological Mechanisms, Trajectories, and Treatment Response, Identification and Characterization of Asymmetrically-Expressed Genes, G822804477, Social & Language Deficits in Autism-Biology & Treament, A Genomewide Search for Autism Susceptibilty Loci
OpenAlex ID: W1981492377