Work

Modern genome editing meets telomeres: the many functions of TPP1

Year: 2014

Type: preprint

Abstract: The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.

Source: Genes & Development

DOI: 10.1101/gad.250316.114

Author: Jan Karlseder

Institution: Salk Institute for Biological Studies

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

Funder: National Institute of General Medical Sciences

Award: G2327767422