Year: 2012
Type: review
Abstract: Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.
Source: Cell Calcium
Institutions: Imperial College London, University of Bristol
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,950
Funders: Wellcome Trust, British Heart Foundation, Royal Society, University of Bristol, European Foundation for the Study of Diabetes, European Association for the Study of Diabetes, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council
Awards: Understanding pancreatic beta cell dysfunction in diabetes., Roles of GWA genes in controlling pancreatic beta cell function and mass., Role of mitochondrial calcium transport in the regulation of insulin secretion, Molecular mechanisms of glucose sending by pancreatic islet b-cells and hypothalamic neurons., Molecular mechanisms of glucose sending by pancreatic islet b-cells and hypothalamic neurons.
OpenAlex ID: W1981526622