Work

An algorithm to generate low-resolution protein tertiary structures from knowledge of secondary structure.

Year: 1994

Type: article

Abstract: An algorithm is described to assemble the three-dimensional fold of a protein starting from its secondary structure. A reduced representation of the polypeptide chain is used together with a crude potential based on pair hydrophobicities. The method is shown to be successful in locating the native topology for two 4-alpha-helix bundles, myohemerythrin and cytochrome b-562.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.91.11.5027

Authors: A Monge, R A Friesner, B Honig

Institution: Columbia University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources

Awards: G4063576775, THEORETICAL SIMULATION OF BIOLOGICAL SYSTEMS, G9000067001