Work

Tandem Dienone Photorearrangement–Cycloaddition for the Rapid Generation of Molecular Complexity

Year: 2013

Type: article

Abstract: A tandem dienone photorearrangement-cycloaddition (DPC) reaction of novel cyclohexadienone substrates tethered with various 2π and 4π reaction partners resulted in the formation of polycyclic, bridged frameworks. In particular, use of alkynyl ether-tethered substrates led to (3 + 2) cycloaddition to afford strained alkenes which could be further elaborated by intra- and intermolecular cycloaddition chemistry to produce complex, polycyclic chemotypes.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja409992m

Authors: Pieter H. Bos, Mitchell T. Antalek, John A. Porco, Corey R. J. Stephenson

Institution: Boston University

Language: English

Topic: Organic Chemistry Cycloaddition Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Complex Chemotypes: Discovery, Methodology, and Library Expansion