Work

Autologous aGVHD Associated with Infusion of T-Cells with Engineered Specificity for NY-ESO-1 and LAGE-1 Following High-Dose Melphalan and ASCT in Patients with Multiple Myeloma

Year: 2013

Type: article

Abstract: Autologous stem cell transplantation (auto-SCT) is uncommonly associated with acute graft-versus-host disease (aGVHD)-like syndromes that are typically mild and self-limited; incidence is increased when auto-SCT is coupled with infusion of ex vivo expanded/costimulated T-cells. We describe here a gastrointestinal GVHD-like syndrome in multiple myeloma (MM) patients treated with auto-SCT and T-regulatory-cell (Treg)-depleted, autologous T-cells genetically modified to express a T-cell receptor with engineered specificity for a HLA-A*02-restricted epitope common to cancer-testis antigens NY-ESO-1 and LAGE-1.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.11.071