Year: 2009
Type: article
Study design: Case Report
Abstract: OBJECTIVE: To investigate the specificity of in vivo amyloid imaging with [(11)C]-Pittsburgh Compound B (PIB) in Parkinson disease dementia (PDD). METHODS: We performed detailed neuropathologic examination for 3 individuals with PDD who had PIB PET imaging within 15 months of death. RESULTS: We observed elevated cortical uptake of [(11)C]-PIB on in vivo PET imaging in 2 of the 3 cases. At autopsy, all 3 individuals had abundant cortical Lewy bodies (Braak PD stage 6), and were classified as low-probability Alzheimer disease (AD) based on NIA-Reagan criteria. The 2 PIB-positive individuals had abundant diffuse Abeta plaques but only sparse neuritic plaques and intermediate neurofibrillary tangle pathology. The PIB-negative individual had rare diffuse plaques, no neuritic plaques, and low neurofibrillary tangle burden. CONCLUSIONS: [(11)C]-Pittsburgh Compound B (PIB) PET is specific for fibrillar Abeta molecular pathology but not for pathologic diagnosis of comorbid Alzheimer disease in individuals with Parkinson disease dementia. The ability to specifically identify fibrillar Abeta amyloid in the setting of alpha-synucleinopathy makes [(11)C]-PIB PET a valuable tool for prospectively evaluating how the presence of Abeta amyloid influences the clinical course of dementia in patients with Lewy body disorders.
Source: Neurology
Institutions: University of Rochester Medicine, University of Rochester
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: National Institutes of Health, U.S. Public Health Service, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Epidemilogy of Parkinsonism in Welders, National Alzheimer's Coordinating Center, EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION, Washington University Center for Translational Neuroscience, G5634531206, CARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISM, MECHANISMS OF DEEP BRAIN STIMULATION, Alzheimer's Disease Research Center, G6928178805, G7043476921, Healthy Aging and Senile Dementia, Washington University Institute of Clinical and Translational Sciences, Pathophysiology of Dystonia and Parkinsonism, Washington University Institute of Clinical and Translational Sciences (UL1), MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD, VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRAITAL NEURONS, Parkinsonian Gait Disorders: Mechanisms and Treatment
OpenAlex ID: W1981881335